{"id":5235,"date":"2025-08-08T10:37:50","date_gmt":"2025-08-08T08:37:50","guid":{"rendered":"https:\/\/stopalzheimer.be\/?p=5235"},"modified":"2025-10-15T15:07:48","modified_gmt":"2025-10-15T13:07:48","slug":"et-si-la-solution-contre-alzheimer-se-trouvait-dans-nos-intestins-stop-alzheimer","status":"publish","type":"post","link":"https:\/\/stopalzheimer.be\/fr\/et-si-la-solution-contre-alzheimer-se-trouvait-dans-nos-intestins-stop-alzheimer\/","title":{"rendered":"Et si la solution contre Alzheimer se trouvait dans nos intestins ?"},"content":{"rendered":"

Et si la solution contre Alzheimer se trouvait dans nos intestins ?<\/h1>\n\n\n\n

On le sait aujourd\u2019hui : nos intestins jouent un r\u00f4le bien plus vaste que la simple digestion. Le microbiote intestinal \u2013 ces milliards de bact\u00e9ries qui peuplent notre syst\u00e8me digestif \u2013 influence une multitude de fonctions dans notre corps. Immunit\u00e9, m\u00e9tabolisme, sant\u00e9 mentale\u2026 les preuves de son importance s\u2019accumulent. Et une piste, encore r\u00e9cente mais tr\u00e8s prometteuse, attire d\u00e9sormais l\u2019attention des chercheurs : le lien entre flore intestinale et maladie d\u2019Alzheimer.<\/p>\n\n\n\n

Une flore intestinale diff\u00e9rente chez les patients Alzheimer<\/h3>\n\n\n\n
\"\"<\/figure>
\n

Plusieurs \u00e9tudes ont mis en \u00e9vidence un d\u00e9s\u00e9quilibre du microbiote intestinal chez les personnes atteintes d\u2019Alzheimer. Certaines bact\u00e9ries sont surrepr\u00e9sent\u00e9es, d\u2019autres au contraire presque absentes. Ce constat soul\u00e8ve une question cruciale : cette modification est- elle une cons\u00e9quence de la maladie, ou pourrait-elle en \u00eatre l\u2019une des causes ?<\/p>\n\n\n\n

Si l\u2019on parvient \u00e0 d\u00e9montrer que certaines bact\u00e9ries favorisent l\u2019apparition ou l\u2019aggravation de la maladie, cela ouvrirait des perspectives totalement nouvelles : d\u00e9pistage pr\u00e9coce, pr\u00e9vention, voire traitements cibl\u00e9s par la modulation du microbiote \u2013 par l\u2019alimentation, des probiotiques ou autres interventions.<\/p>\n<\/div><\/div>\n\n\n\n

<\/h3>\n\n\n\n

Une chercheuse belge \u00e0 la pointe de cette r\u00e9volution<\/h3>\n\n\n\n

En Belgique, le laboratoire de Roos Vandenbroucke (VIB \u2013 Universit\u00e9 de Gand) m\u00e8ne actuellement une recherche de pointe sur ce sujet, soutenue par la Fondation Stop Alzheimer. Elle s\u2019int\u00e9resse en particulier \u00e0 une bact\u00e9rie appel\u00e9e Akkermansia muciniphila<\/em>, bien connue pour ses effets b\u00e9n\u00e9fiques sur la sant\u00e9 intestinale.<\/p>\n\n\n\n

Mais Akkermansia <\/em>pourrait aussi jouer un r\u00f4le protecteur dans les maladies neurod\u00e9g\u00e9n\u00e9ratives. Son \u00e9quipe \u00e9tudie notamment les v\u00e9sicules extracellulaires bact\u00e9riennes (bEVs), de minuscules particules produites par la bact\u00e9rie, capables de transporter des prot\u00e9ines, lipides ou fragments d\u2019ARN. Ces v\u00e9sicules peuvent traverser la barri\u00e8re h\u00e9mato-enc\u00e9phalique et atteindre le cerveau, o\u00f9 elles pourraient moduler l\u2019inflammation ou d\u2019autres processus li\u00e9s \u00e0 Alzheimer.<\/p>\n\n\n\n

Une approche holistique et prometteuse<\/h3>\n\n\n\n

Le projet de Roos Vandenbroucke adopte une approche compl\u00e8te. En plus de l\u2019effet sur le cerveau, son \u00e9quipe analyse les m\u00e9canismes biologiques qui sous-tendent cette interaction intestin-cerveau :<\/p>\n\n\n\n

    \n
  • la communication via le nerf vague,<\/li>\n\n\n\n
  • le r\u00f4le des barri\u00e8res protectrices dans l\u2019intestin et le cerveau,<\/li>\n\n\n\n
  • la r\u00e9action du syst\u00e8me immunitaire,<\/li>\n\n\n\n
  • et la circulation des v\u00e9sicules dans tout l\u2019organisme.<\/li>\n<\/ul>\n\n\n\n

    Ce regard nouveau et multidisciplinaire sur Alzheimer est porteur d\u2019espoir : il sugg\u00e8re que la maladie pourrait, dans certains cas, \u00eatre influenc\u00e9e \u2013 voire frein\u00e9e \u2013 par des interventions cibl\u00e9es sur notre microbiote.<\/p>\n\n\n\n

    <\/p>\n\n\n\n

    Soutenir une recherche innovante, ici en Belgique<\/h3>\n\n\n\n

    Ce projet illustre parfaitement le type de recherche innovante que la Fondation Stop Alzheimer a choisi de financer. En explorant de nouvelles voies et en bousculant nos repr\u00e9sentations classiques de la maladie, ces \u00e9tudes ouvrent la voie \u00e0 de nouvelles strat\u00e9gies de pr\u00e9vention et de traitement.<\/strong> Parce que comprendre, c\u2019est d\u00e9j\u00e0 progresser. Et que pr\u00e9venir, c\u2019est aussi prot\u00e9ger les g\u00e9n\u00e9rations futures. Merci pour votre soutien. C\u2019est gr\u00e2ce \u00e0 votre g\u00e9n\u00e9rosit\u00e9 que la recherche progresse<\/p>\n\n\n\n

    <\/p>","protected":false},"excerpt":{"rendered":"

    Et si la solution contre Alzheimer se trouvait dans nos intestins ? On le sait aujourd\u2019hui : nos intestins jouent un r\u00f4le bien plus vaste que la simple digestion. Le microbiote intestinal \u2013 ces milliards de bact\u00e9ries qui peuplent notre syst\u00e8me digestif \u2013 influence une multitude de fonctions dans notre corps. Immunit\u00e9, m\u00e9tabolisme, sant\u00e9 mentale\u2026 […]<\/p>\n","protected":false},"author":8,"featured_media":5243,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[29],"tags":[],"locatie":[26,28],"class_list":["post-5235","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-onderzoek","locatie-homepage","locatie-over-alzheimer"],"acf":[],"yoast_head":"\nEt si la solution contre Alzheimer se trouvait dans nos intestins ? - Stop Alzheimer<\/title>\n<meta name=\"description\" content=\"Le r\u00f4le cl\u00e9 du microbiote intestinal dans la maladie d\u2019Alzheimer. 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