{"id":4122,"date":"2024-12-03T08:46:56","date_gmt":"2024-12-03T07:46:56","guid":{"rendered":"https:\/\/stopalzheimer.be\/?p=4122"},"modified":"2024-12-04T07:37:41","modified_gmt":"2024-12-04T06:37:41","slug":"cas-hereditaires-dalzheimer-une-avancee-majeure-signee-par-des-chercheurs-belges","status":"publish","type":"post","link":"https:\/\/stopalzheimer.be\/fr\/cas-hereditaires-dalzheimer-une-avancee-majeure-signee-par-des-chercheurs-belges\/","title":{"rendered":"Cas h\u00e9r\u00e9ditaires d\u2019Alzheimer : une avanc\u00e9e majeure sign\u00e9e par des chercheurs belges"},"content":{"rendered":"

Cas h\u00e9r\u00e9ditaires d\u2019Alzheimer : une avanc\u00e9e majeure sign\u00e9e par des chercheurs belges<\/h2>\n\n\n\n

La maladie d’Alzheimer, d\u00e9vastatrice par ses effets sur la m\u00e9moire et les fonctions cognitives, repr\u00e9sente un d\u00e9fi colossal pour la recherche m\u00e9dicale. Parmi ses formes, l’Alzheimer familiale, rare et h\u00e9r\u00e9ditaire, offre des cl\u00e9s cruciales pour mieux comprendre les m\u00e9canismes de cette pathologie. Une \u00e9quipe de chercheurs belges, dirig\u00e9e par le Professeur Wim Annaert, a fait une d\u00e9couverte d\u00e9terminante dans ce domaine. Leurs travaux, soutenus par notre fondation et publi\u00e9s dans Nature Communications<\/a>, mettent en lumi\u00e8re le r\u00f4le central d\u2019un g\u00e8ne jusqu\u2019alors peu connu, PSEN2, dans l\u2019acc\u00e9l\u00e9ration des processus pathologiques de la maladie.<\/p>\n\n\n\n

Un g\u00e8ne, deux m\u00e9canismes destructeurs<\/strong><\/p>\n\n\n\n

Dans la maladie d’Alzheimer, la formation de plaques amylo\u00efdes dans le cerveau est l\u2019un des marqueurs principaux. Ces plaques r\u00e9sultent de l\u2019accumulation de fragments toxiques de prot\u00e9ines, appel\u00e9s amylo\u00efde \u03b2 (A\u03b2), g\u00e9n\u00e9r\u00e9s par un complexe enzymatique, la \u03b3-s\u00e9cr\u00e9tase. Si le r\u00f4le de PSEN1, une des deux variantes de ce complexe, \u00e9tait bien document\u00e9, celui de PSEN2 restait un myst\u00e8re\u2026 jusqu\u2019\u00e0 cette \u00e9tude.<\/p>\n\n\n\n

Les chercheurs belges ont montr\u00e9 que les mutations du g\u00e8ne PSEN2 aggravent la maladie par deux m\u00e9canismes\u202f:<\/p>\n\n\n\n

    \n
  1. Production amplifi\u00e9e de fragments amylo\u00efdes toxiques : <\/strong>ces mutations augmentent la quantit\u00e9 d’amylo\u00efde \u03b2, acc\u00e9l\u00e9rant la formation des plaques.<\/li>\n\n\n\n
  2. D\u00e9faillance du syst\u00e8me de recyclage cellulaire :<\/strong> les cellules c\u00e9r\u00e9brales, surcharg\u00e9es par les d\u00e9chets qu\u2019elles ne parviennent plus \u00e0 \u00e9liminer, subissent des dommages et perdent leur capacit\u00e9 \u00e0 communiquer efficacement. <\/li>\n<\/ol>\n\n\n\n

    Cette \u00ab double attaque \u00bb perturbe directement les synapses, ces connexions vitales entre les neurones, exacerbant ainsi la perte de m\u00e9moire et le d\u00e9clin cognitif.<\/p>\n\n\n\n

    Des implications pour de futures th\u00e9rapies<\/strong><\/p>\n\n\n\n

    \u00ab Comprendre comment les mutations de PSEN2 agissent est une \u00e9tape cl\u00e9 <\/em>\u00bb, explique le Professeur Wim Annaert. \u00ab Ces nouvelles connaissances nous permettent d\u2019envisager des traitements cibl\u00e9s, qu\u2019il s\u2019agisse de restaurer le syst\u00e8me de recyclage cellulaire ou d\u2019optimiser l\u2019efficacit\u00e9 de la \u03b3-s\u00e9cr\u00e9tase.<\/em> \u00bb
    Pour Anika Perdok, premi\u00e8re auteure de l\u2019\u00e9tude, cette recherche ouvre des perspectives pr\u00e9cieuses pour ralentir la progression de la maladie chez les patients atteints d’Alzheimer familial. \u00ab Cette double attaque, que nous avons identifi\u00e9e, nous donne des pistes claires pour intervenir sur plusieurs fronts. <\/em>\u00bb<\/p>\n\n\n\n

    Un pas de plus vers des traitements personnalis\u00e9s<\/strong><\/p>\n\n\n\n

    Cette avanc\u00e9e offre non seulement un \u00e9clairage sur les cas h\u00e9r\u00e9ditaires de la maladie, mais pourrait \u00e9galement enrichir notre compr\u00e9hension des formes sporadiques de la maladie. \u00c0 mesure que les m\u00e9canismes sous-jacents sont d\u00e9voil\u00e9s, les chercheurs se rapprochent d\u2019interventions th\u00e9rapeutiques adapt\u00e9es, capables de freiner la progression de cette maladie qui touche des millions de personnes \u00e0 travers le monde.<\/p>\n\n\n\n

    Merci \u00e0 nos donateurs de permettre le financement de telles recherches. <\/p>\n\n\n\n

    La presse en parle : <\/em><\/strong><\/p>\n\n\n\n

      \n
    • RTL <\/strong>: https:\/\/www.rtl.be\/actu\/magazine\/sante\/une-avancee-majeure-des-chercheurs-belges-identifient-un-gene-cle-dans\/2024-12-03\/article\/730556<\/li>\n\n\n\n
    • DH<\/strong> : https:\/\/www.dhnet.be\/dernieres-depeches\/2024\/12\/03\/une-etude-belge-identifie-un-gene-cle-dans-lacceleration-de-la-maladie-dalzheimer-YGUQE7YBCNCQ5OVGZ2UYW4QD44\/<\/li>\n\n\n\n
    • La Libre<\/strong> : https:\/\/www.lalibre.be\/dernieres-depeches\/2024\/12\/03\/une-etude-belge-identifie-un-gene-cle-dans-lacceleration-de-la-maladie-dalzheimer-YGUQE7YBCNCQ5OVGZ2UYW4QD44\/<\/li>\n\n\n\n
    • Sudinfo<\/strong> : https:\/\/www.sudinfo.be\/id923677\/article\/2024-12-03\/une-etude-belge-identifie-un-gene-cle-dans-lacceleration-de-la-maladie<\/li>\n\n\n\n
    • Plus Magazine<\/strong> : https:\/\/www.plusmagazine.be\/fr\/sante\/un-gene-cle-semble-intervenir-dans-lacceleration-de-la-maladie-dalzheimer\/<\/li>\n<\/ul>\n\n\n\n

      <\/p>","protected":false},"excerpt":{"rendered":"

      Cas h\u00e9r\u00e9ditaires d\u2019Alzheimer : une avanc\u00e9e majeure sign\u00e9e par des chercheurs belges La maladie d’Alzheimer, d\u00e9vastatrice par ses effets sur la m\u00e9moire et les fonctions cognitives, repr\u00e9sente un d\u00e9fi colossal pour la recherche m\u00e9dicale. Parmi ses formes, l’Alzheimer familiale, rare et h\u00e9r\u00e9ditaire, offre des cl\u00e9s cruciales pour mieux comprendre les m\u00e9canismes de cette pathologie. Une […]<\/p>\n","protected":false},"author":3,"featured_media":4123,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4,29],"tags":[],"locatie":[27,26,28,41],"class_list":["post-4122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actie-in-de-kijker","category-onderzoek","locatie-help-mee","locatie-homepage","locatie-over-alzheimer","locatie-pers"],"acf":[],"yoast_head":"\nCas h\u00e9r\u00e9ditaires d\u2019Alzheimer : une avanc\u00e9e majeure sign\u00e9e par des chercheurs belges - Stop Alzheimer<\/title>\n<meta name=\"description\" content=\"L'Alzheimer familiale, rare et h\u00e9r\u00e9ditaire, offre des cl\u00e9s cruciales pour mieux comprendre les m\u00e9canismes de la pathologie.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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